human VPS4A Over-expression AAV

Name
AAV-h-VPS4A

Cat No
AAV-227544

Availability
4-5 weeks

This is an AAV expressing Human VPS4A.

AAV-227544

AAV-h-VPS4A

Ready-to-use AAV expressing Human VPS4A (vacuolar protein sorting 4 homolog A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

SKD1; SKD1A; SKD2; VPS4; VPS4-1

Description (Vector)

VPS4A is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.

Gene ID

27183

Gene Name (Vector)

vacuolar protein sorting 4 homolog A

Gene Symbol

VPS4A

HGNC ID

HGNC:13488

ORF Size (aa)

1314

RefSeq ID

NM_013245

RefSeq Synonyms

NM_013245, BC047932,

Species

human

UniGene ID

Hs.128420

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.