human VPS4A shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human VPS4A.
shADV-227544
Ad-h-VPS4A-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human VPS4A (vacuolar protein sorting 4 homolog A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
SKD1; SKD1A; SKD2; VPS4; VPS4-1
Description (Vector)
VPS4A is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.
Gene ID
27183
Gene Name (Vector)
vacuolar protein sorting 4 homolog A
Gene Symbol
VPS4A
HGNC ID
HGNC:13488
ORF Size (aa)
1314
RefSeq ID
NM_013245
RefSeq Synonyms
NM_013245, BC047932,
Species
human
UniGene ID
Hs.128420
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.