human POLH Over-expression AAV

Name 
AAV-h-POLH
Cat No 
AAV-219367
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human POLH.

AAV-219367
AAV-h-POLH

Ready-to-use AAV expressing Human POLH (DNA polymerase eta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DNA polymerase eta; polymerase (DNA directed), eta; polymerase (DNA) eta; RAD30; RAD30 homolog A; RAD30A; xeroderma pigmentosum variant type protein; XPV; XP-V
Description (eCommerce)
PolH is a DNA polymerase specifically involved in DNA repair and somatic hypermutation. Defects in PolH result in a variant type of xeroderma pigmentosum, a disease characterized by sunlight hypersensitivity, increased incidence of cancer, and neurological abnormalities.
Description (Vector)
POLH encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum.
Gene ID
5429
Gene Name (eCommerce)
DNA polymerase eta
Gene Name (Vector)
DNA polymerase eta
Gene Symbol
POLH
HGNC ID
HGNC:9181
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1245
ORF Size (bp)
1245 bp
Protein Name (eCommerce)
DNA polymerase eta
RefSeq ID
NM_006502
RefSeq Synonyms
NM_006502, NM_001291970, NM_001291969, BC015742,
Research Areas
DNA Damage/Repair,DNA Replication,Fanconi anemia
Research Areas (Faceted)
genetics,transcription_translation,cell_biology
Species
human
Target Sentence
PolH is a DNA polymerase specifically involved in DNA repair and somatic hypermutation. Defects in PolH result in a variant type of xeroderma pigmentosum, a disease characterized by sunlight hypersensitivity, increased incidence of cancer, and neurological abnormalities.
UniGene ID
Hs.655467
UniProt ID (eCommerce)
Q9Y253

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.