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human SBDS shRNA silencing Adenovirus

Name 
Ad-h-SBDS-shRNA
Cat No 
shADV-222279
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SBDS.

shADV-222279
Ad-h-SBDS-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SBDS (SBDS ribosome assembly guanine nucleotide exchange factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CGI-97; ribosome maturation protein SBDS; SBDS, ribosome assembly guanine nucleotide exchange factor; SDS; Shwachman-Bodian-Diamond syndrome protein; SWDS
Description (eCommerce)
Shwachman-Bodian-Diamond Syndrome/SBDS is required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, it triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. SBDS is required for normal levels of protein synthesis. It may play a role in cellular stress resistance and cellular response to DNA damage. It may also play a role in cell proliferation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y3A5].
Description (Vector)
SBDS encodes a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The encoded protein may function in RNA metabolism. Mutations within this gene are associated with Shwachman-Bodian-Diamond syndrome. An alternative transcript has been described, but its biological nature has not been determined. SBDS has a closely linked pseudogene that is distally located.
Gene ID
51119
Gene Name (eCommerce)
SBDS, ribosome maturation factor
Gene Name (Vector)
SBDS ribosome assembly guanine nucleotide exchange factor
Gene Symbol
SBDS
HGNC ID
HGNC:19440
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
753
Protein Name (eCommerce)
Ribosome maturation protein SBDS
RefSeq ID
NM_016038
RefSeq Synonyms
NM_016038, BC065700,
Research Areas
Cell Cycle,Cytoskeleton,Immunology,RNA Binding,RNA Processing
Research Areas (Faceted)
cell_biology,cell_cycle,immunology,genetics,transcription_translation
Species
human
Target Sentence
Shwachman-Bodian-Diamond Syndrome/SBDS is required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, it triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. SBDS is required for normal levels of protein synthesis. It may play a role in cellular stress resistance and cellular response to DNA damage. It may also play a role in cell proliferation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y3A5].
UniGene ID
Hs.110445
UniProt ID (eCommerce)
Q9Y3A5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.