human MASP1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MASP1.
shADV-215056
Ad-h-MASP1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MASP1 (mannan binding lectin serine peptidase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
3MC1; CRARF; CRARF1; MAP1; MAp44; MASP; MASP3; PRSS5; RaRF
Description (Vector)
MASP1 encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.
Gene ID
5648
Gene Name (Vector)
mannan binding lectin serine peptidase 1
Gene Symbol
MASP1
HGNC ID
HGNC:6901
ORF Size (aa)
2187
ORF Size (bp)
2187 bp
RefSeq ID
NM_139125
RefSeq Synonyms
NM_139125, NM_001879, NM_001031849, BC106946, BC106945,
Species
human
UniGene ID
Hs.89983
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.