mouse MASP1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Masp1.
shAAV-264283
AAV-m-MASP1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Masp1 (mannan-binding lectin serine peptidase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AW048060; CCPII; Crarf; Masp1/3
Description (Vector)
Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.
Gene ID
17174
Gene Name (Vector)
mannan-binding lectin serine peptidase 1
Gene Symbol
Masp1
ORF Size (aa)
2115
ORF Size (bp)
2115 bp
RefSeq ID
NM_008555
RefSeq Synonyms
NM_008555, BC131638, BC131637,
Species
mouse
UniGene ID
Mm.1213
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.