rat MASP1 shRNA silencing AAV

Name
AAV-r-MASP1-shRNA

Cat No
shAAV-293768

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Rat Masp1.

shAAV-293768

AAV-r-MASP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Rat Masp1 (mannan-binding lectin serine peptidase 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Masp1/3; Masp3

Description (Vector)

Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.

Gene ID

64023

Gene Name (Vector)

mannan-binding lectin serine peptidase 1

Gene Symbol

Masp1

ORF Size (aa)

1158

ORF Size (bp)

1158 bp

RefSeq ID

NM_022257

RefSeq Synonyms

NM_022257, BC085685,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.