human MAP3K8 shRNA silencing AAV

Name
AAV-h-MAP3K8-shRNA

Cat No
shAAV-214942

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human MAP3K8.

shAAV-214942

AAV-h-MAP3K8-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MAP3K8 (mitogen-activated protein kinase kinase kinase 8). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AURA2; c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2

Description (Vector)

MAP3K8 is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. MAP3K8 may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.

Gene ID

1326

Gene Name (Vector)

mitogen-activated protein kinase kinase kinase 8

Gene Symbol

MAP3K8

HGNC ID

HGNC:6860

ORF Size (aa)

1404

ORF Size (bp)

1404 bp

RefSeq ID

NM_005204

RefSeq Synonyms

NM_005204, NM_001320961, NM_001244134, BC113566, BC104833,

Species

human

UniGene ID

Hs.432453

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.