mouse MAP3K8 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Map3k8.
shAAV-264198
AAV-m-MAP3K8-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Map3k8 (mitogen-activated protein kinase kinase kinase 8). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
c-COT; Cot; Cot/Tpl2; Est; Estf; Tpl-2; Tpl2
Description (Vector)
Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein.
Gene ID
26410
Gene Name (Vector)
mitogen-activated protein kinase kinase kinase 8
Gene Symbol
Map3k8
ORF Size (aa)
1404
ORF Size (bp)
1404 bp
RefSeq ID
NM_007746
RefSeq Synonyms
NM_007746, BC137922, BC125286,
Species
mouse
UniGene ID
Mm.3275
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.