human MAP3K8 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MAP3K8.
shADV-214942
Ad-h-MAP3K8-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MAP3K8 (mitogen-activated protein kinase kinase kinase 8). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AURA2; c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2
Description (Vector)
MAP3K8 is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. MAP3K8 may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.
Gene ID
1326
Gene Name (Vector)
mitogen-activated protein kinase kinase kinase 8
Gene Symbol
MAP3K8
HGNC ID
HGNC:6860
ORF Size (aa)
1404
ORF Size (bp)
1404 bp
RefSeq ID
NM_005204
RefSeq Synonyms
NM_005204, NM_001320961, NM_001244134, BC113566, BC104833,
Species
human
UniGene ID
Hs.432453
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.