mouse CDKN1A shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Cdkn1a.
shADV-277593
Ad-m-CDKN1A-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Cdkn1a (cyclin-dependent kinase inhibitor 1A (P21)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CAP20; CDKI; Cdkn1; CIP1; mda6; P21; p21Cip1; p21WAF; SDI1; Waf1
Description (Vector)
CDKN1A may be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
Gene ID
12575
Gene Name (Vector)
cyclin-dependent kinase inhibitor 1A (P21)
Gene Symbol
Cdkn1a
ORF Size (aa)
480
ORF Size (bp)
480 bp
RefSeq ID
NM_007669
RefSeq Synonyms
NM_007669, NM_001111099, BC002043,
Species
mouse
UniGene ID
Mm.477981
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.