mouse CDKN1A shRNA silencing AAV

Cat. No: shAAV-277593

Availability: 6-8 weeks

Name: AAV-m-CDKN1A-shRNA

This is an AAV expressing shRNA for silencing of Mouse Cdkn1a.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Cdkn1a
Gene Name: cyclin-dependent kinase inhibitor 1A (P21)
Gene ID: 12575
Gene Synonyms: CAP20; CDKI; Cdkn1; CIP1; mda6; P21; p21Cip1; p21WAF; SDI1; Waf1
ORF Size: 480 bp
RefSeq#: NM_007669
Gene Description: CDKN1A may be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
UniGene ID: Mm.477981