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mouse VPS36 shRNA silencing Adenovirus

Name 
Ad-m-VPS36-shRNA
Cat No 
shADV-276061
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Vps36.

shADV-276061
Ad-m-VPS36-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Vps36 (vacuolar protein sorting 36). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
1700010A24Rik; 2210415M20Rik; 2810408E15Rik; Eap45
Description (Vector)
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.
Gene ID
70160
Gene Name (Vector)
vacuolar protein sorting 36
Gene Symbol
Vps36
ORF Size (aa)
1161
ORF Size (bp)
1161 bp
RefSeq ID
NM_027338
RefSeq Synonyms
NM_027338, BC010811,
Species
mouse
UniGene ID
Mm.474298

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.