mouse RNF40 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Rnf40.
shADV-270747
Ad-m-RNF40-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Rnf40 (ring finger protein 40). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI848422; mKIAA0661
Description (Vector)
Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.
Gene ID
233900
Gene Name (Vector)
ring finger protein 40
Gene Symbol
Rnf40
ORF Size (aa)
3006
ORF Size (bp)
3006 bp
RefSeq ID
NM_172281
RefSeq Synonyms
NM_172281, BC038348,
Species
mouse
UniGene ID
Mm.41122
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.