human RNF40 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human RNF40.
shADV-221431
Ad-h-RNF40-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human RNF40 (ring finger protein 40). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
95 kDa retinoblastoma protein binding protein; 95 kDa retinoblastoma-associated protein; BRE1 E3 ubiquitin ligase homolog B; BRE1B; BRE1-B; E3 ubiquitin-protein ligase BRE1B; Rb-associated protein; RBP95; RING finger protein 40; ring finger protein 40, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase BRE1B; STARING
Description (eCommerce)
The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes. Targeting of proteins by ubiquitination occurs in three main steps that involve the activation of ubiquitin by E1 enzymes, the carrying of ubiquitin to the target protein by E2 enzymes and the ligation of ubiquitin to the target protein by E3 enzymes. Ring finger protein 40 (RNF40) is a member of the RING type E3 ubiquitin ligases. RNF40 forms a complex with RNF20 to carry out H2B monoubiquitination in association with hPAF and the UbcH6 ubiquitin E2-conjugating enzyme. H2B monoubiquitination by RN40/RNF20 has been shown to be associated with increased H3 methylation and gene transcription.
Description (Vector)
RNF40 contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
9810
Gene Name (eCommerce)
ring finger protein 40
Gene Name (Vector)
ring finger protein 40
Gene Symbol
RNF40
HGNC ID
HGNC:16867
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3006
ORF Size (bp)
3006 bp
Protein Name (eCommerce)
E3 ubiquitin-protein ligase BRE1B
RefSeq ID
NM_014771
RefSeq Synonyms
NM_014771, NM_001286572, NM_001207034, NM_001207033, BC018647, BC011769, BC006133,
Research Areas
Chromatin Remodeling,Histone Modification,Neurobiology,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cell_biology,genetics,neurobiology
Species
human
Target Sentence
The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes. Targeting of proteins by ubiquitination occurs in three main steps that involve the activation of ubiquitin by E1 enzymes, the carrying of ubiquitin to the target protein by E2 enzymes and the ligation of ubiquitin to the target protein by E3 enzymes. Ring finger protein 40 (RNF40) is a member of the RING type E3 ubiquitin ligases. RNF40 forms a complex with RNF20 to carry out H2B monoubiquitination in association with hPAF and the UbcH6 ubiquitin E2-conjugating enzyme. H2B monoubiquitination by RN40/RNF20 has been shown to be associated with increased H3 methylation and gene transcription.
UniGene ID
Hs.65238
UniProt ID (eCommerce)
O75150
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.