mouse EGFR shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Egfr.
shADV-258137
Ad-m-EGFR-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Egfr (epidermal growth factor receptor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
9030024J15Rik; AI552599; Erbb; Errb1; Errp; wa-2; wa2; Wa5
Description (Vector)
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin|Function: Isoform 2 may act as an antagonist of EGF action.
Gene ID
13649
Gene Name (Vector)
epidermal growth factor receptor
Gene Symbol
Egfr
ORF Size (aa)
1968
ORF Size (bp)
1968 bp
RefSeq ID
NM_207655
RefSeq Synonyms
NM_207655, NM_007912, BC023729,
Species
mouse
UniGene ID
Mm.439882
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.