mouse ITM2B shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Itm2b.
shADV-252337
Ad-m-ITM2B-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Itm2b (integral membrane protein 2B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI256040; Bri; Bri2; Bricd2b; D14Sel6; E25BMM; imBRI2
Description (Vector)
Plays a regulatory role in the processing of the beta-amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites|Function: Mature BRI2 (mBRI2) functions as a modulator of the beta-amyloid A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed beta-amyloid protein 40 and beta-amyloid protein 42|Function: Bri23 peptide prevents aggregation of APP beta-amyloid protein 42 peptide into toxic oligomers.
Gene ID
16432
Gene Name (Vector)
integral membrane protein 2B
Gene Symbol
Itm2b
ORF Size (aa)
801
RefSeq ID
NM_008410
RefSeq Synonyms
NM_008410, BC021786, BC010320, BC004731,
Species
mouse
UniGene ID
Mm.4266
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.