human ITM2B shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human ITM2B.
shAAV-212536
AAV-h-ITM2B-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human ITM2B (integral membrane protein 2B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ABRI; BRI; BRI2; BRICD2B; E25B; E3-16; FBD; imBRI2; RDGCA
Description (Vector)
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
Gene ID
9445
Gene Name (Vector)
integral membrane protein 2B
Gene Symbol
ITM2B
HGNC ID
HGNC:6174
ORF Size (aa)
801
ORF Size (bp)
801 bp
RefSeq ID
NM_021999
RefSeq Synonyms
NM_021999, BC016148, BC000554,
Species
human
UniGene ID
Hs.643683
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.