human UGT1A8 shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-229143
Availability:
5-8 weeks
Name:
Ad-h-UGT1A8-shRNA
This is an Adenovirus expressing shRNA for silencing of Human UGT1A8.
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Product Info
- Knockdown
- shRNA screening service available, please inquire about this service or other options.
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- UGT1A8
- Gene Name
- UDP glucuronosyltransferase family 1 member A8
- Gene ID
- 54576
- Gene Synonyms
- UDPGT; UDPGT 1-8; UGT-1H; UGT1-08; UGT1.8; UGT1A8S; UGT1H
- ORF Size
- 1593 bp
- RefSeq#
- NM_019076
- Gene Description
- UGT1A8 encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. UGT1A8 is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids.
- UniGene ID
- Hs.
- HGNC ID
- HGNC:12540
Related Products
Product | Cat No. |
---|---|
AAV-h-UGT1A8 | AAV-229143 |
Ad-h-UGT1A8 | ADV-229143 |
AAV-h-UGT1A8-shRNA | shAAV-229143 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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