human UGT1A8 Over-expression AAV
This is an AAV expressing Human UGT1A8.
AAV-229143
AAV-h-UGT1A8
Ready-to-use AAV expressing Human UGT1A8 (UDP glucuronosyltransferase family 1 member A8). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
UDPGT; UDPGT 1-8; UGT-1H; UGT1-08; UGT1.8; UGT1A8S; UGT1H
Description (Vector)
UGT1A8 encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. UGT1A8 is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids.
Gene ID
54576
Gene Name (Vector)
UDP glucuronosyltransferase family 1 member A8
Gene Symbol
UGT1A8
HGNC ID
HGNC:12540
ORF Size (aa)
1593
ORF Size (bp)
1593 bp
RefSeq ID
NM_019076
RefSeq Synonyms
NM_019076, BC156848,
Species
human
UniGene ID
Hs.
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.