human TOP3B shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TOP3B.
shADV-226207
Ad-h-TOP3B-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TOP3B (topoisomerase (DNA) III beta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
TOP3B1
Description (Vector)
TOP3B encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described.
Gene ID
8940
Gene Name (Vector)
topoisomerase (DNA) III beta
Gene Symbol
TOP3B
HGNC ID
HGNC:11993
ORF Size (aa)
2589
ORF Size (bp)
2589 bp
RefSeq ID
NM_003935
RefSeq Synonyms
NM_003935, NM_001282113, NM_001282112, BC002432,
Species
human
UniGene ID
Hs.436401
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.