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human TOP3B shRNA silencing AAV

Name 
AAV-h-TOP3B-shRNA
Cat No 
shAAV-226207
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TOP3B.

shAAV-226207
AAV-h-TOP3B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TOP3B (topoisomerase (DNA) III beta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
TOP3B1
Description (Vector)
TOP3B encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described.
Gene ID
8940
Gene Name (Vector)
topoisomerase (DNA) III beta
Gene Symbol
TOP3B
HGNC ID
HGNC:11993
ORF Size (aa)
2589
ORF Size (bp)
2589 bp
RefSeq ID
NM_003935
RefSeq Synonyms
NM_003935, NM_001282113, NM_001282112, BC002432,
Species
human
UniGene ID
Hs.436401

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.