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human SPOP shRNA silencing Adenovirus

Name 
Ad-h-SPOP-shRNA
Cat No 
shADV-224227
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SPOP.

shADV-224227
Ad-h-SPOP-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SPOP (speckle type BTB/POZ protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
BTBD32; TEF2
Description (Vector)
SPOP encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.
Gene ID
8405
Gene Name (Vector)
speckle type BTB/POZ protein
Gene Symbol
SPOP
HGNC ID
HGNC:11254
ORF Size (aa)
1125
ORF Size (bp)
1125 bp
RefSeq ID
NM_003563
RefSeq Synonyms
NM_003563, NM_001007230, NM_001007229, NM_001007228, NM_001007227, NM_001007226, BC003385, BC001269,
Species
human
UniGene ID
Hs.718421

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.