human SMC5 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SMC5.
shADV-223739
Ad-h-SMC5-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SMC5 (structural maintenance of chromosomes 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
hSMC5; SMC protein 5; SMC-5; SMC5 structural maintenance of chromosomes 5-like 1; SMC5L1; structural maintenance of chromosomes protein 5
Description (eCommerce)
SMC (Structural maintenance of chromosomes) proteins are members of multisubunit complexes that play a critical role in chromosome organization, segregation, gene regulation, and DNA repair. Two of these complexes, cohesin and condensin consist of a core complex of an SMC1 and SMC3 heterodimer or an SMC2 and SMC4 heterodimer, respectively. A third complex includes a heterodimer of SMC5 and SMC6 whose function is not fully understood but is proposed to be related to DNA repair.
Gene ID
23137
Gene Name (eCommerce)
structural maintenance of chromosomes 5
Gene Name (Vector)
structural maintenance of chromosomes 5
Gene Symbol
SMC5
HGNC ID
HGNC:20465
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3306
ORF Size (bp)
3306 bp
Protein Name (eCommerce)
Structural maintenance of chromosomes protein 5
RefSeq ID
NM_015110
RefSeq Synonyms
NM_015110, BC038225,
Research Areas
Cell Cycle,Cell Division,DNA Damage/Repair,Homologous Recombination,Telomeric Maintenance
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
SMC (Structural maintenance of chromosomes) proteins are members of multisubunit complexes that play a critical role in chromosome organization, segregation, gene regulation, and DNA repair. Two of these complexes, cohesin and condensin consist of a core complex of an SMC1 and SMC3 heterodimer or an SMC2 and SMC4 heterodimer, respectively. A third complex includes a heterodimer of SMC5 and SMC6 whose function is not fully understood but is proposed to be related to DNA repair.
UniGene ID
Hs.601181
UniProt ID (eCommerce)
Q8IY18
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.