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human SMC5 shRNA silencing AAV

Name 
AAV-h-SMC5-shRNA
Cat No 
shAAV-223739
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SMC5.

shAAV-223739
AAV-h-SMC5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SMC5 (structural maintenance of chromosomes 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
hSMC5; SMC protein 5; SMC-5; SMC5 structural maintenance of chromosomes 5-like 1; SMC5L1; structural maintenance of chromosomes protein 5
Description (eCommerce)
SMC (Structural maintenance of chromosomes) proteins are members of multisubunit complexes that play a critical role in chromosome organization, segregation, gene regulation, and DNA repair. Two of these complexes, cohesin and condensin consist of a core complex of an SMC1 and SMC3 heterodimer or an SMC2 and SMC4 heterodimer, respectively. A third complex includes a heterodimer of SMC5 and SMC6 whose function is not fully understood but is proposed to be related to DNA repair.
Gene ID
23137
Gene Name (eCommerce)
structural maintenance of chromosomes 5
Gene Name (Vector)
structural maintenance of chromosomes 5
Gene Symbol
SMC5
HGNC ID
HGNC:20465
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3306
ORF Size (bp)
3306 bp
Protein Name (eCommerce)
Structural maintenance of chromosomes protein 5
RefSeq ID
NM_015110
RefSeq Synonyms
NM_015110, BC038225,
Research Areas
Cell Cycle,Cell Division,DNA Damage/Repair,Homologous Recombination,Telomeric Maintenance
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
SMC (Structural maintenance of chromosomes) proteins are members of multisubunit complexes that play a critical role in chromosome organization, segregation, gene regulation, and DNA repair. Two of these complexes, cohesin and condensin consist of a core complex of an SMC1 and SMC3 heterodimer or an SMC2 and SMC4 heterodimer, respectively. A third complex includes a heterodimer of SMC5 and SMC6 whose function is not fully understood but is proposed to be related to DNA repair.
UniGene ID
Hs.601181
UniProt ID (eCommerce)
Q8IY18

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.