mouse SMC5 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Smc5.
shAAV-272633
AAV-m-SMC5-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Smc5 (structural maintenance of chromosomes 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
mKIAA0594; MLZ-453; mSMC5; SMC-5; Smc5l1
Description (Vector)
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6.
Gene ID
226026
Gene Name (Vector)
structural maintenance of chromosomes 5
Gene Symbol
Smc5
ORF Size (aa)
1836
ORF Size (bp)
1836 bp
RefSeq ID
NM_153808
RefSeq Synonyms
NM_153808, NM_001252685, NM_001252684, BC038345, BC007174,
Species
mouse
UniGene ID
Mm.23267
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.