human RASSF1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human RASSF1.
shADV-220797
Ad-h-RASSF1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human RASSF1 (Ras association domain family member 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
123F2; NORE2A; RASSF1A; RDA32; REH3P21
Description (Vector)
RASSF1 encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Gene ID
11186
Gene Name (Vector)
Ras association domain family member 1
Gene Symbol
RASSF1
HGNC ID
HGNC:9882
ORF Size (aa)
1023
ORF Size (bp)
1023 bp
RefSeq ID
NM_007182
RefSeq Synonyms
NM_170714, NM_170713, NM_170712, NM_007182, NM_001206957, BC143879, BC117153, BC110412,
Species
human
UniGene ID
Hs.476270
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.