human PRF1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PRF1.
shADV-219811
Ad-h-PRF1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PRF1 (perforin 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
FLH2; HPLH2; P1; PFN1; PFP
Description (Vector)
PRF1 has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.
Gene ID
5551
Gene Name (Vector)
perforin 1
Gene Symbol
PRF1
HGNC ID
HGNC:9360
ORF Size (aa)
1668
ORF Size (bp)
1668 bp
RefSeq ID
NM_005041
RefSeq Synonyms
NM_005041, NM_001083116, BC063043, BC047695,
Species
human
UniGene ID
Hs.2200
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.