mouse PRF1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Prf1.
shAAV-269342
AAV-m-PRF1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Prf1 (perforin 1 (pore forming protein)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Pfn; Pfp; Prf-1
Description (Vector)
Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.
Gene ID
18646
Gene Name (Vector)
perforin 1 (pore forming protein)
Gene Symbol
Prf1
ORF Size (aa)
1665
ORF Size (bp)
1665 bp
RefSeq ID
NM_011073
RefSeq Synonyms
NM_011073, BC137962, BC132300,
Species
mouse
UniGene ID
Mm.240313
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.