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human PARP10 shRNA silencing Adenovirus

Name 
Ad-h-PARP10-shRNA
Cat No 
shADV-218231
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PARP10.

shADV-218231
Ad-h-PARP10-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PARP10 (poly(ADP-ribose) polymerase family member 10). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ADP-ribosyltransferase diphtheria toxin-like 10; ARTD10; PARP-10; poly ADP-ribose polymerase 10
Description (eCommerce)
PARP10 is a member of the poly(ADP-ribose) polymerase (PARP) family involved in a variety of processes which includes DNA metabolism, the DNA damage response, transcription and the maintenance of genomic stability. Although each member of the PARP family exhibits poly(ADP-ribose) polymerase activity which catalyzes the attachment of ADP-ribose units from NAD+ to substrate proteins, the endogenous substrates of many of the family members, including PARP10, remain to be identified. Recent studies have shown that PARP10 is localized to the nucleoli and associates with RNA polymerase II. PARP10 is a substrate of and is activated by CDK2 and may serve an important function in cell proliferation.
Description (Vector)
Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 (PubMed 15674325)).(supplied by OMIM, Mar 2008)
Gene ID
84875
Gene Name (eCommerce)
poly(ADP-ribose) polymerase family member 10
Gene Name (Vector)
poly(ADP-ribose) polymerase family member 10
Gene Symbol
PARP10
HGNC ID
HGNC:25895
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3078
ORF Size (bp)
3078 bp
Protein Name (eCommerce)
Poly [ADP-ribose] polymerase 10
RefSeq ID
NM_032789
RefSeq Synonyms
NM_032789, NM_001317895, BC136542, BC132961,
Research Areas
Chromatin Remodeling,Golgi Apparatus,Histone Modification,Transcription Factor/Regulator
Research Areas (Faceted)
transcription_translation,cell_biology,genetics
Species
human
Target Sentence
PARP10 is a member of the poly(ADP-ribose) polymerase (PARP) family involved in a variety of processes which includes DNA metabolism, the DNA damage response, transcription and the maintenance of genomic stability. Although each member of the PARP family exhibits poly(ADP-ribose) polymerase activity which catalyzes the attachment of ADP-ribose units from NAD+ to substrate proteins, the endogenous substrates of many of the family members, including PARP10, remain to be identified. Recent studies have shown that PARP10 is localized to the nucleoli and associates with RNA polymerase II. PARP10 is a substrate of and is activated by CDK2 and may serve an important function in cell proliferation.
UniGene ID
Hs.348609
UniProt ID (eCommerce)
Q53GL7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.