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human IL4R Over-expression AAV

Name 
AAV-h-IL4R
Cat No 
AAV-212196
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human IL4R.

AAV-212196
AAV-h-IL4R

Ready-to-use AAV expressing Human IL4R (interleukin 4 receptor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD124; IL-4RA; IL4RA
Description (Vector)
IL4R encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
Gene ID
3566
Gene Name (Vector)
interleukin 4 receptor
Gene Symbol
IL4R
HGNC ID
HGNC:6015
ORF Size (aa)
2478
ORF Size (bp)
2478 bp
RefSeq ID
NM_000418
RefSeq Synonyms
NM_001257997, NM_001257407, NM_001257406, NM_001008699, NM_000418, BC151131, BC136365,
Species
human
UniGene ID
Hs.513457

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.