human IL4R shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human IL4R.
shADV-212196
Ad-h-IL4R-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human IL4R (interleukin 4 receptor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD124; IL-4RA; IL4RA
Description (Vector)
IL4R encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
Gene ID
3566
Gene Name (Vector)
interleukin 4 receptor
Gene Symbol
IL4R
HGNC ID
HGNC:6015
ORF Size (aa)
2478
ORF Size (bp)
2478 bp
RefSeq ID
NM_000418
RefSeq Synonyms
NM_001257997, NM_001257407, NM_001257406, NM_001008699, NM_000418, BC151131, BC136365,
Species
human
UniGene ID
Hs.513457
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.