human MSH4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MSH4.
shADV-215910
Ad-h-MSH4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MSH4 (mutS homolog 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
MSH4 encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair.
Gene ID
4438
Gene Name (Vector)
mutS homolog 4
Gene Symbol
MSH4
HGNC ID
HGNC:7327
ORF Size (aa)
2811
ORF Size (bp)
2811 bp
RefSeq ID
NM_002440
RefSeq Synonyms
NM_002440, BC033030,
Species
human
UniGene ID
Hs.216639
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.