human MSH4 shRNA silencing AAV

Name
AAV-h-MSH4-shRNA

Cat No
shAAV-215910

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human MSH4.

shAAV-215910

AAV-h-MSH4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MSH4 (mutS homolog 4). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

MSH4 encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair.

Gene ID

4438

Gene Name (Vector)

mutS homolog 4

Gene Symbol

MSH4

HGNC ID

HGNC:7327

ORF Size (aa)

2811

ORF Size (bp)

2811 bp

RefSeq ID

NM_002440

RefSeq Synonyms

NM_002440, BC033030,

Species

human

UniGene ID

Hs.216639

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.