human KPNA6 shRNA silencing Adenovirus

Name
Ad-h-KPNA6-shRNA

Cat No
shADV-213349

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human KPNA6.

shADV-213349

Ad-h-KPNA6-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human KPNA6 (karyopherin subunit alpha 6). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

IPOA7; KPNA7

Description (Vector)

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family.

Gene ID

23633

Gene Name (Vector)

karyopherin subunit alpha 6

Gene Symbol

KPNA6

HGNC ID

HGNC:6399

ORF Size (aa)

1611

ORF Size (bp)

1611 bp

RefSeq ID

NM_012316

RefSeq Synonyms

NM_012316, BC020520,

Species

human

UniGene ID

Hs.711019

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.