mouse KPNA6 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Kpna6.
shAAV-263041
AAV-m-KPNA6-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Kpna6 (karyopherin (importin) alpha 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
IPOA7; Kpna5; NPI-2
Description (Vector)
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Gene ID
16650
Gene Name (Vector)
karyopherin (importin) alpha 6
Gene Symbol
Kpna6
ORF Size (aa)
1611
ORF Size (bp)
1611 bp
RefSeq ID
NM_008468
RefSeq Synonyms
NM_008468, BC004833,
Species
mouse
UniGene ID
Mm.202358
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.