human HMGN1 shRNA silencing Adenovirus

Name 
Ad-h-HMGN1-shRNA
Cat No 
shADV-211286
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human HMGN1.

shADV-211286
Ad-h-HMGN1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human HMGN1 (high mobility group nucleosome binding domain 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
high mobility group nucleosome-binding domain-containing protein 1; high-mobility group (nonhistone chromosomal) protein 14; high-mobility group nucleosome binding 1; HMG14; non-histone chromosomal protein HMG-14; nonhistone chromosomal protein HMG-14
Description (eCommerce)
HMGN1 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA to potentially alter the interaction between the DNA and the histone octamer. The two proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function [taken from NCBI Entrez Gene (GeneID:3150)].
Description (Vector)
HMGN1 binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes.
Gene ID
3150
Gene Name (eCommerce)
high mobility group nucleosome binding domain 1
Gene Name (Vector)
high mobility group nucleosome binding domain 1
Gene Symbol
HMGN1
HGNC ID
HGNC:4984
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
303
Protein Name (eCommerce)
Non-histone chromosomal protein HMG-14
RefSeq ID
NM_004965
RefSeq Synonyms
NM_004965, BC107741, BC106080, BC072672, BC071643, BC070154, BC070153, BC023984, BC000075,
Research Areas
DNA Damage/Repair,Host-Virus Interactions,MAPK Signaling,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,infectious_disease,signal_transduction,transcription_translation
Species
human
Target Sentence
HMGN1 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA to potentially alter the interaction between the DNA and the histone octamer. The two proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function [taken from NCBI Entrez Gene (GeneID:3150)].
UniGene ID
Hs.356285
UniProt ID (eCommerce)
P05114

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.