human EYA2 shRNA silencing Adenovirus

Name 
Ad-h-EYA2-shRNA
Cat No 
shADV-208208
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human EYA2.

shADV-208208
Ad-h-EYA2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human EYA2 (EYA transcriptional coactivator and phosphatase 2). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
EAB1; eyes absent homolog 2
Description (eCommerce)
EYA2 (eyes absent homolog 2) functions as a tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX. EYA2 promotes efficient DNA repair by dephosphorylating H2AX and promoting the recruitment of DNA repair complexes containing MDC1. EYA2 coactivates SIX1. Together with SIX1 and DACH2 EYA2 seems to be involved in myogenesis. EYA2 may be involved in development of the eye [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O00167].
Description (Vector)
EYA2 encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined.
Gene ID
2139
Gene Name (eCommerce)
EYA transcriptional coactivator and phosphatase 2
Gene Name (Vector)
EYA transcriptional coactivator and phosphatase 2
Gene Symbol
EYA2
HGNC ID
HGNC:3520
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1545
ORF Size (bp)
1545 bp
Protein Name (eCommerce)
Eyes absent homolog 2
RefSeq ID
NM_005244
RefSeq Synonyms
NM_172110, NM_005244, BC008803,
Research Areas
Apoptosis,DNA Damage/Repair,Histone Modification,Kinase/Phosphatase,Mitochondrion,Phosphatase,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
EYA2 (eyes absent homolog 2) functions as a tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX. EYA2 promotes efficient DNA repair by dephosphorylating H2AX and promoting the recruitment of DNA repair complexes containing MDC1. EYA2 coactivates SIX1. Together with SIX1 and DACH2 EYA2 seems to be involved in myogenesis. EYA2 may be involved in development of the eye [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O00167].
UniGene ID
Hs.472877
UniProt ID (eCommerce)
O00167

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.