human CITED4 shRNA silencing Adenovirus

Name 
Ad-h-CITED4-shRNA
Cat No 
shADV-205301
Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Human CITED4.

shADV-205301
Ad-h-CITED4-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CITED4 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Description (Vector)
The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors.
Gene ID
163732
Gene Name (Vector)
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
Gene Symbol
CITED4
HGNC ID
HGNC:18696
ORF Size (aa)
555
RefSeq ID
NM_133467
RefSeq Synonyms
NM_133467, BC052559, BC035496,
Species
human
UniGene ID
Hs.355820

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.