human CITED4 shRNA silencing AAV

Name
AAV-h-CITED4-shRNA

Cat No
shAAV-205301

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CITED4.

shAAV-205301

AAV-h-CITED4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CITED4 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors.

Gene ID

163732

Gene Name (Vector)

Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4

Gene Symbol

CITED4

HGNC ID

HGNC:18696

ORF Size (aa)

555

RefSeq ID

NM_133467

RefSeq Synonyms

NM_133467, BC052559, BC035496,

Species

human

UniGene ID

Hs.355820

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.