human ABCB1 shRNA silencing Adenovirus

Name
Ad-h-ABCB1-shRNA

Cat No
shADV-200056

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Human ABCB1.

shADV-200056

Ad-h-ABCB1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ABCB1 (ATP binding cassette subfamily B member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

ABC20; ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; CD antigen CD243; CD243; CLCS; colchicin sensitivity; doxorubicin resistance; GP170; MDR1; multidrug resistance protein 1; P glycoprotein; P-glycoprotein 1; P-GP; PGY1

Description (eCommerce)

Multidrug resistance protein 1 (MDR1) is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). MDR1 is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. MDR1 is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. MDR1 also functions as a transporter in the blood-brain barrier [taken from NCBI Entrez Gene (Gene ID: 5243)].

Description (Vector)

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Gene ID

5243

Gene Name (eCommerce)

ATP binding cassette subfamily B member 1

Gene Name (Vector)

ATP binding cassette subfamily B member 1

Gene Symbol

ABCB1

HGNC ID

HGNC:40

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

3843

ORF Size (bp)

3843 bp

Protein Name (eCommerce)

Multidrug resistance protein 1

RefSeq ID

NM_000927

RefSeq Synonyms

NM_000927, BC130424,

Research Areas

Cancer,Cardiology,Cardiovascular,Cell Cycle,Golgi Apparatus,Hypoxia,Metabolism/Metabolic Process,MicroRNAs in Cancer,Neurobiology,Transport

Research Areas (Faceted)

cancer,genetics,cardiovascular,cell_biology,cell_cycle,metabolism,neurobiology,cell_biology

Species

human

Target Sentence

UniGene ID

Hs.489033

UniProt ID (eCommerce)

P08183

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.