rat RASSF1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Rat Rassf1.
shAAV-291526
AAV-r-RASSF1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Rat Rassf1 (Ras association domain family member 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.
Gene ID
363140
Gene Name (Vector)
Ras association domain family member 1
Gene Symbol
Rassf1
ORF Size (aa)
813
RefSeq ID
NM_001007754
RefSeq Synonyms
NM_001037555, NM_001007754, BC079237,
Species
rat
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.