mouse SOX2 shRNA silencing AAV

Name
AAV-m-SOX2-shRNA

Cat No
shAAV-272885

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Sox2.

shAAV-272885

AAV-m-SOX2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Sox2 (SRY (sex determining region Y)-box 2). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

lcc; Sox-2; ysb

Description (Vector)

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).

Gene ID

20674

Gene Name (Vector)

SRY (sex determining region Y)-box 2

Gene Symbol

Sox2

ORF Size (aa)

960

RefSeq ID

NM_011443

RefSeq Synonyms

NM_011443, BC057574,

Species

mouse

UniGene ID

Mm.65396

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.