human SOX2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SOX2.
shADV-224023
Ad-h-SOX2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SOX2 (SRY-box 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ANOP3; MCOPS3; sex determining region Y-box 2; SRY (sex determining region Y)-box 2; SRY-related HMG-box gene 2; transcription factor SOX2; transcription factor SOX-2
Description (eCommerce)
SRY (sex determining region Y)- box 2 (SOX2) is a transcription factor involved in embryonic development and is critical to embryonic stem cell pluripotency. Mutations in the SOX2 gene are associated with microphthalmia syndromic type 3 (MCOPS3) a condition characterized by microphthalmia or anophthalmia.
Description (Vector)
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
Gene ID
6657
Gene Name (eCommerce)
SRY-box 2
Gene Name (Vector)
SRY-box 2
Gene Symbol
SOX2
HGNC ID
HGNC:11195
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
954
Protein Name (eCommerce)
Transcription factor SOX-2
RefSeq ID
NM_003106
RefSeq Synonyms
NM_003106, BC013923,
Research Areas
Brain Development,Cardiac Development,Cardiology,Cardiovascular,Cell Cycle,Gene Expression,Hippo Signaling,MAPK Signaling,Neurobiology,Neurodevelopment,Notch Signaling,RNA Binding,Signal Transduction,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
signal_transduction,neurobiology,developmental_biology,cardiovascular,cell_biology,cell_cycle,genetics,transcription_translation,signal_transduction,developmental_biology,signal_transduction,neurobiology,developmental_biology,signal_transduction,genetics,transcription_translation,signal_transduction,developmental_biology
Species
human
Target Sentence
SRY (sex determining region Y)- box 2 (SOX2) is a transcription factor involved in embryonic development and is critical to embryonic stem cell pluripotency. Mutations in the SOX2 gene are associated with microphthalmia syndromic type 3 (MCOPS3) a condition characterized by microphthalmia or anophthalmia.
UniGene ID
Hs.518438
UniProt ID (eCommerce)
P48431
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.