mouse NOX4 shRNA silencing AAV
Category: AAV > shRNA-Silencing
Cat. No: shAAV-265956
Availability:
6-8 weeks
Name:
AAV-m-NOX4-shRNA
This is an AAV expressing shRNA for silencing of Mouse Nox4.
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Product Info
- Knockdown
- shRNA screening service available, please inquire about this service or other options.
Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Nox4
- Gene Name
- NADPH oxidase 4
- Gene ID
- 50490
- Gene Synonyms
- AI648021
- ORF Size
- 1737 bp
- RefSeq#
- NM_015760
- Gene Description
- Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displays an increased activity. Isoform 5 and isoform 6 display reduced activity.
- UniGene ID
- Mm.31748
Related Products
Product | Cat No. |
---|---|
AAV-h-NOX4 | AAV-230059 |
AAV-m-NOX4 | AAV-265956 |
Ad-h-NOX4 | ADV-230059 |
Ad-m-NOX4 | ADV-265956 |
AAV-h-NOX4-shRNA | shAAV-230059 |
Ad-h-NOX4-shRNA | shADV-230059 |
Ad-m-NOX4-shRNA | shADV-265956 |
Control Products
Product | Cat No. |
---|---|
AAV1-GFP-U6-shRNA | 7040 |
AAV2-GFP-U6-shRNA | 7041 |
AAV5-GFP-U6-shRNA | 7042 |
AAV6-GFP-U6-shRNA | 7043 |
AAV9-GFP-U6-shRNA | 7045 |
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