mouse NFKBIA shRNA silencing AAV

Name
AAV-m-NFKBIA-shRNA

Cat No
shAAV-265725

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Nfkbia.

shAAV-265725

AAV-m-NFKBIA-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Nfkbia (nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AI462015; Nfkbi

Description (Vector)

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Gene ID

18035

Gene Name (Vector)

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

Gene Symbol

Nfkbia

ORF Size (aa)

945

ORF Size (bp)

945 bp

RefSeq ID

NM_010907

RefSeq Synonyms

NM_010907, BC046754,

Species

mouse

UniGene ID

Mm.170515

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.