mouse KDM5B shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Kdm5b.
shAAV-262769
AAV-m-KDM5B-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Kdm5b (lysine (K)-specific demethylase 5B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2010009J12Rik; 2210016I17Rik; AW556288; D1Ertd202e; Jarid1b; mKIAA4034; PLU-1; Plu1; PUT1; Rb-Bp2; RBBP2H1A
Description (Vector)
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.
Gene ID
75605
Gene Name (Vector)
lysine (K)-specific demethylase 5B
Gene Symbol
Kdm5b
ORF Size (aa)
4635
ORF Size (bp)
4635 bp
RefSeq ID
NM_152895
RefSeq Synonyms
NM_152895, BC057318, BC048180,
Species
mouse
UniGene ID
Mm.391994
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.