mouse ESRP2 shRNA silencing AAV

Name
AAV-m-ESRP2-shRNA

Cat No
shAAV-258719

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Esrp2.

shAAV-258719

AAV-m-ESRP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Esrp2 (epithelial splicing regulatory protein 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

9530027K23Rik; Rbm35b

Description (Vector)

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.

Gene ID

77411

Gene Name (Vector)

epithelial splicing regulatory protein 2

Gene Symbol

Esrp2

ORF Size (aa)

2154

ORF Size (bp)

2154 bp

RefSeq ID

NM_176838

RefSeq Synonyms

NM_176838, BC031444,

Species

mouse

UniGene ID

Mm.183003

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.