mouse CACNA1G shRNA silencing AAV

Name
AAV-m-CACNA1G-shRNA

Cat No
shAAV-254366

Availability
Immediate

This is an AAV expressing shRNA for silencing of Mouse Cacna1g.

shAAV-254366

AAV-m-CACNA1G-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Cacna1g (calcium channel, voltage-dependent, T type, alpha 1G subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

a1G; alpha-1G; Cav3.1d; mKIAA1123; [a]1G

Description (Vector)

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

Gene ID

12291

Gene Name (Vector)

calcium channel, voltage-dependent, T type, alpha 1G subunit

Gene Symbol

Cacna1g

ORF Size (aa)

6747

ORF Size (bp)

6747 bp

RefSeq ID

NM_009783

RefSeq Synonyms

NM_009783, NM_001177890, NM_001177888, NM_001112813, BC057399,

Species

mouse

UniGene ID

Mm.29585

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.