mouse ADAM17 shRNA silencing AAV

Name 
AAV-m-ADAM17-shRNA
Cat No 
shAAV-252038
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Adam17.

shAAV-252038
AAV-m-ADAM17-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Adam17 (a disintegrin and metallopeptidase domain 17). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD156b; Tace
Description (Vector)
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity).
Gene ID
11491
Gene Name (Vector)
a disintegrin and metallopeptidase domain 17
Gene Symbol
Adam17
ORF Size (aa)
2484
ORF Size (bp)
2484 bp
RefSeq ID
NM_009615
RefSeq Synonyms
NM_009615, NM_001291871, NM_001277266, BC145270, BC138420, BC138416, BC114999, BC094655,
Species
mouse
UniGene ID
Mm.27681

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.